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KMID : 1188320090030010031
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Gut and Liver
2009 Volume.3 No. 1 p.31 ~ p.34
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Treatment of Gastric Candidiasis in Patients with Gastric Ulcer Disease: Are Antifungal Agents Necessary?
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Jung Min-Kyu
Jeon Seong-Woo
Cho Chang-Min
Tak Won-Young
Kweon Young-Oh
Kim Sung-Kook
Choi Yong-Hwan
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Abstract
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Background/Aims: The inadequacy of information on the treatment of gastric candidiasis with antifungal agents promoted us to evaluate patients with fungal infections who had gastric ulcers and assess the need for proton-pump inhibitors or antifungal agents.
Methods: Sixteen patients were included in the study. The criterion for the diagnosis of candidiasis was finding
yeast and hyphae in the tissue or an ulcer on histological sections of biopsy samples. Surface fungi were not considered infections.
Results: In all cases with benign ulcers, follow-up endoscopy performed 6 weeks after proton-pump-inhibitor treatment revealed that the ulcer had improved without antifungal medication. However, in patients with malignant ulcers,
surgical resection was necessary for a definitive cure. Two patients with lymphoma received combined chemotherapy
and a proton-pump inhibitor, which improved their condition.
Conclusions: The results of this study suggest that benign ulcers with candidiasis can be effectively treated by a proton-pump inhibitor without antifungal medication. However, surgical resection should be considered for malignant ulcers with candidiasis.
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KEYWORD
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Candidiasis, Antifungal agents, Stomach ulcer, Proton pump inhibitors
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